TY - JOUR
T1 - Translating Koch's postulates to identify matrix metalloproteinase roles in postmyocardial infarction remodeling
T2 - Cardiac metalloproteinase actions (carMA) postulates
AU - Iyer, Rugmani Padmanabhan
AU - De Castro Brás, Lisandra E.
AU - Jin, Yu Fang
AU - Lindsey, Merry L.
PY - 2014/2/28
Y1 - 2014/2/28
N2 - The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. KochÊs postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to include methods to establish molecular causality. In this review, we outline the concept for establishing a similar approach to determine causality in terms of MMP functions. We use left ventricular remodeling postmyocardial infarction as an example, but this approach will have broad applicability across both the cardiovascular and the MMP fields.
AB - The first matrix metalloproteinase (MMP) was described in 1962; and since the 1990s, cardiovascular research has focused on understanding how MMPs regulate many aspects of cardiovascular pathology from atherosclerosis formation to myocardial infarction and stroke. Although much information has been gleaned by these past reports, to a large degree MMP cardiovascular biology remains observational, with few studies homing in on cause and effect relationships. KochÊs postulates were first developed in the 19th century as a way to establish microorganism function and were modified in the 20th century to include methods to establish molecular causality. In this review, we outline the concept for establishing a similar approach to determine causality in terms of MMP functions. We use left ventricular remodeling postmyocardial infarction as an example, but this approach will have broad applicability across both the cardiovascular and the MMP fields.
KW - Extracellular matrix
KW - fibrosis
KW - inflammation
KW - matrix metalloproteinases
KW - proteomics
KW - ventricular remodeling
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U2 - 10.1161/CIRCRESAHA.114.301673
DO - 10.1161/CIRCRESAHA.114.301673
M3 - Review article
C2 - 24577966
AN - SCOPUS:84896780190
VL - 114
SP - 860
EP - 871
JO - Circulation Research
JF - Circulation Research
SN - 0009-7330
IS - 5
ER -