Translocation (1;4)(p31;q34) in nonossifying fibroma

Marilu Nelson, Deborah Perry, Glen Ginsburg, Warren G. Sanger, James R. Neff, Julia A. Bridge

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Nonossifying fibroma is a benign, lytic lesion of fibrous origin most often observed in the metaphyseal region of the long bones in children and adolescents. It is frequently asymptomatic and is often characterized by a history of spontaneous resolution. Herein, we report a clinicohistopathologically typical case of nonossifying fibroma arising in the tibia of an 18-year-old skeletally mature female. Conventional cytogenetic analysis revealed a reciprocal translocation involving bands 1p31 and 4q34 [t(1;4)(p31;q34)]. To the best of our knowledge, this is only the second reported case of a clonally aberrant nonossifying fibroma.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalCancer genetics and cytogenetics
Volume142
Issue number2
DOIs
StatePublished - Apr 15 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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