Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia

Muhamed Baljevic, Omar Abdel-Wahab, Raajit Rampal, Peter G. Maslak, Virginia M. Klimek, Todd L. Rosenblat, Dan Douer, Ross L. Levine, Martin S. Tallman

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Translocation t(11;17) is a well-recognized variant of acute promyelocytic leukemia (APL) and has also been identified in patients with mixed-lineage leukemia (MLL) non-APL acute myeloid leukemia. Here, we describe two patients bearing translocation t(11;17) presenting with a clinical diagnosis of de novo myelodysplastic syndrome (MDS): the first with sole karyotypic abnormality 46,XY,t(11;17)(p11.2; p13) and the second where it represented one of the two karyotypic abnormalities 46,XX,del(5)(q13q33)46,XX,del(5)(q13q33),t(11;17) (q24;q23). Molecular characterization of both cases failed to identify fusion transcripts involving MLL or PLZF-RARA and no collaborating somatic mutations commonly found among MDS patients were seen in either case, suggesting the presence of an as yet unidentified oncogenic fusion protein.

Original languageEnglish (US)
Pages (from-to)48-54
Number of pages7
JournalActa Haematologica
Volume129
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Myelodysplastic syndrome
  • Promyelocytic leukemia
  • Translocation t(11;17)

ASJC Scopus subject areas

  • Hematology

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    Baljevic, M., Abdel-Wahab, O., Rampal, R., Maslak, P. G., Klimek, V. M., Rosenblat, T. L., Douer, D., Levine, R. L., & Tallman, M. S. (2013). Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia. Acta Haematologica, 129(1), 48-54. https://doi.org/10.1159/000342493