Translocation t(12;17)(q24.1;q21) as the sole anomaly in a nasal chondromesenchymal hamartoma arising in a patient with pleuropulmonary blastoma

Radwa El Behery, Jiri Bedrnicek, Audrey Lazenby, Marilu Nelson, Jennifer Grove, Dali Huang, Russell Smith, Julia A. Bridge

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The identification of recurrent chromosomal abnormalities in benign and malignant mesenchymal neoplasms has provided important pathogenetic insight as well as powerful diagnostic adjuncts. Nasal chondromesenchymal hamartoma (NCMH), an extremely rare benign tumor arising in the sinonasal tract of infants and children, has not been previously subjected to cytogenetic analysis. Histopathologically composed of mixed mesenchymal elements, NCMH exhibits a relatively wide differential diagnosis to include chondromyxoid fibroma, chondroblastoma, aneurysmal bone cyst, fibrous dysplasia, and osteochondromyxoma. An interesting association with pleuropulmonary blastoma has been reported in a small subset of NCMH patients. In the current study, cytogenetic analysis of a NCMH arising in an 11-year-old boy with a past medical history of pleuropulmonary blastoma revealed a novel 12;17 translocation, t(12;17)(q24.1;q21), as the sole anomaly.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalPediatric and Developmental Pathology
Volume15
Issue number3
DOIs
StatePublished - Aug 27 2012

Keywords

  • Cytogenetics
  • Karyotype
  • Nasal chondromesenchymal hamartoma
  • Pleuropulmonary blastoma
  • Translocation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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