Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

Matthew R. Mendlick; Marilu Nelson; Diane Pickering; Sonny L. Johansson; Thomas A. Seemayer; James R. Neff; Gerardo Vergara; Howard Rosenthal; Julia A. Bridge

doi:10.1097/00000478-200105000-00019

Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

Matthew R. Mendlick, Marilu Nelson, Diane Pickering, Sonny L. Johansson, Thomas A. Seemayer, James R. Neff, Gerardo Vergara, Howard Rosenthal, Julia A. Bridge

Pathology & Microbiology

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.

Original language	English (US)
Pages (from-to)	684-687
Number of pages	4
Journal	American Journal of Surgical Pathology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1097/00000478-200105000-00019
State	Published - 2001

Keywords

Chromosome
Cytogenetics
Hemangioendothelioma
Karyotype
Vascular tumors

ASJC Scopus subject areas

Anatomy
Surgery
Pathology and Forensic Medicine

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10.1097/00000478-200105000-00019

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title = "Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma",

abstract = "The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.",

keywords = "Chromosome, Cytogenetics, Hemangioendothelioma, Karyotype, Vascular tumors",

author = "Mendlick, {Matthew R.} and Marilu Nelson and Diane Pickering and Johansson, {Sonny L.} and Seemayer, {Thomas A.} and Neff, {James R.} and Gerardo Vergara and Howard Rosenthal and Bridge, {Julia A.}",

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doi = "10.1097/00000478-200105000-00019",

language = "English (US)",

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pages = "684--687",

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T1 - Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

AU - Mendlick, Matthew R.

AU - Nelson, Marilu

AU - Pickering, Diane

AU - Johansson, Sonny L.

AU - Seemayer, Thomas A.

AU - Neff, James R.

AU - Vergara, Gerardo

AU - Rosenthal, Howard

AU - Bridge, Julia A.

PY - 2001

Y1 - 2001

N2 - The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.

AB - The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.

KW - Chromosome

KW - Cytogenetics

KW - Hemangioendothelioma

KW - Karyotype

KW - Vascular tumors

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Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

Abstract

Keywords

ASJC Scopus subject areas

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