Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma

Matthew R. Mendlick, Marilu Nelson, Diane Pickering, Sonny L. Johansson, Thomas A. Seemayer, James R. Neff, Gerardo Vergara, Howard Rosenthal, Julia A. Bridge

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.

Original languageEnglish (US)
Pages (from-to)684-687
Number of pages4
JournalAmerican Journal of Surgical Pathology
Volume25
Issue number5
DOIs
StatePublished - 2001

Keywords

  • Chromosome
  • Cytogenetics
  • Hemangioendothelioma
  • Karyotype
  • Vascular tumors

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma'. Together they form a unique fingerprint.

Cite this