Translocation t(X;18) in orofacial synovial sarcoma

Julia A. Bridge, Robert S. Bridge, Deborah A. Borek, Barbara Shaffer, Charley W. Norris

Research output: Contribution to journalArticle

49 Scopus citations


Cytogenetic analysis of a synovial sarcoma of the base of the tongue showed a reciprocal translocation involving chromosomes X and 18 [t(X;18)(p11.2;q11.2)]. This is a translocation recently reported to be characteristic of synovial sarcomas of the extremities. The histogenesis of synovial sarcoma is controversial. Our discovery of this translocation in an oral synovial sarcoma confirms the unity of origin of this neoplasm with the far more common synovial sarcomas of the extremity. Karyotypic analysis may prove useful in confirming the diagnosis of this uncommon neoplasm.

Original languageEnglish (US)
Pages (from-to)935-937
Number of pages3
Issue number5
StatePublished - Sep 1 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Bridge, J. A., Bridge, R. S., Borek, D. A., Shaffer, B., & Norris, C. W. (1988). Translocation t(X;18) in orofacial synovial sarcoma. Cancer, 62(5), 935-937.<935::AID-CNCR2820620514>3.0.CO;2-E