Transmission of maternal muscle-specific tyrosine kinase (MuSK) to offspring: Report of two cases

Earnest L. Murray; Sachin Kedar; V. V. Vedanarayanan

doi:10.1097/CND.0b013e3181f8a9aa

Transmission of maternal muscle-specific tyrosine kinase (MuSK) to offspring: Report of two cases

Earnest L. Murray, Sachin Kedar, V. V. Vedanarayanan

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Familial occurrence of myasthenia gravis is uncommon and reports of maternal transmission of muscle-specific tyrosine kinase (MuSK) antibody myasthenia are rarer still. We report two families with maternal transmission of MuSK antibody myasthenia gravis to the offspring by different mechanisms. The first family demonstrates transmission genetic susceptibility of inheriting myasthenia gravis from MuSK antibodies, whereas the second one demonstrates transplacental transmission of MuSK antibodies at birth.

Original language	English (US)
Pages (from-to)	76-79
Number of pages	4
Journal	Journal of Clinical Neuromuscular Disease
Volume	12
Issue number	2
DOIs	https://doi.org/10.1097/CND.0b013e3181f8a9aa
State	Published - Dec 2010
Externally published	Yes

Keywords

Inherited musk antibodies
Transient neonatal musk antibodies
Transmission of MuSK antibodies

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1097/CND.0b013e3181f8a9aa

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title = "Transmission of maternal muscle-specific tyrosine kinase (MuSK) to offspring: Report of two cases",

abstract = "Familial occurrence of myasthenia gravis is uncommon and reports of maternal transmission of muscle-specific tyrosine kinase (MuSK) antibody myasthenia are rarer still. We report two families with maternal transmission of MuSK antibody myasthenia gravis to the offspring by different mechanisms. The first family demonstrates transmission genetic susceptibility of inheriting myasthenia gravis from MuSK antibodies, whereas the second one demonstrates transplacental transmission of MuSK antibodies at birth.",

keywords = "Inherited musk antibodies, Transient neonatal musk antibodies, Transmission of MuSK antibodies",

author = "Murray, {Earnest L.} and Sachin Kedar and Vedanarayanan, {V. V.}",

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T2 - Report of two cases

AU - Murray, Earnest L.

AU - Kedar, Sachin

AU - Vedanarayanan, V. V.

PY - 2010/12

Y1 - 2010/12

N2 - Familial occurrence of myasthenia gravis is uncommon and reports of maternal transmission of muscle-specific tyrosine kinase (MuSK) antibody myasthenia are rarer still. We report two families with maternal transmission of MuSK antibody myasthenia gravis to the offspring by different mechanisms. The first family demonstrates transmission genetic susceptibility of inheriting myasthenia gravis from MuSK antibodies, whereas the second one demonstrates transplacental transmission of MuSK antibodies at birth.

AB - Familial occurrence of myasthenia gravis is uncommon and reports of maternal transmission of muscle-specific tyrosine kinase (MuSK) antibody myasthenia are rarer still. We report two families with maternal transmission of MuSK antibody myasthenia gravis to the offspring by different mechanisms. The first family demonstrates transmission genetic susceptibility of inheriting myasthenia gravis from MuSK antibodies, whereas the second one demonstrates transplacental transmission of MuSK antibodies at birth.

KW - Inherited musk antibodies

KW - Transient neonatal musk antibodies

KW - Transmission of MuSK antibodies

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AN - SCOPUS:78651495931

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JF - Journal of Clinical Neuromuscular Disease

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ER -

Transmission of maternal muscle-specific tyrosine kinase (MuSK) to offspring: Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

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