Transplantation, Immunology, and Cell Biology

Leslie Kobayashi, Emily Cantrell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This is a unique question-and-answer chapter for surgical residents and trainees, concentrating on transplantation, immunology, and cell biology. The best treatment for hepatorenal syndrome is liver transplantation. Drug-drug interactions with various immunosuppressants continue to be a clinically significant problem affecting many transplant recipients. Both tacrolimus and cyclosporine are classified as calcineurin inhibitors (CNI) and often used in maintenance of immunosuppression following solid organ transplant. Malignancy is more frequent in posttransplant patients than in the general population with the most common malignancy being squamous cell skin cancers. The risk of invasive fungal infection (IFI) is increased in patients after a solid organ transplant and is associated with decreased survival. The three leading causes of late death following renal transplant are cardiovascular disease, malignancy, and infections. Cytomegalovirus (CMV) is one of the most common viral pathogens causing clinical disease following solid organ transplant.

Original languageEnglish (US)
Title of host publicationSurgical Critical Care and Emergency Surgery
Subtitle of host publicationClinical Questions and Answers: Second Edition
PublisherWiley-Blackwell
Pages209-217
Number of pages9
ISBN (Electronic)9781119317913
ISBN (Print)9781119317920
DOIs
StatePublished - Apr 3 2018
Externally publishedYes

Keywords

  • Calcineurin inhibitors
  • Cell biology
  • Cytomegalovirus
  • Drug-drug interactions
  • Immunosuppression
  • Invasive fungal infection
  • Liver transplantation
  • Posttransplant patients
  • Renal transplant

ASJC Scopus subject areas

  • General Medicine

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