Transplanted small bowel and expression of the insulin-like growth factor binding proteins

Mark R. Corkins, Stuart S. Kaufman, Jon A. Vanderhoof, Yvette Milazzo, Genevieve Holtz, Richard G. MacDonald, Alan Langnas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The insulin-like growth factor binding proteins (IGFBPs) act to modulate the growth and differentiation of the gastrointestinal mucosa by regulating cellular responses to the important mitogens, the insulin-like growth factors (IGFs). The transplanted small bowel must maintain the normal growth factor interrelationships and signaling pathways despite the potential of host rejection. Ostomy effluent of patients after small bowel or combined liver/small bowel transplantation was assayed for IGFBPs to investigate the effect of rejection on the IGF-IGFBP axis. Seventeen patients were studied over an 18-month period. The transplanted small bowel produced no measurable IGFBPs in the ostomy effluent under normal circumstances. However, when rejection was taking place the ostomy effluent was found to have measurable IGFBP levels in 6 of 12 episodes, the 6 episodes occurring in 6 different patients. Mostly, the IGFBPs present did not exhibit a serum-like pattern indicating the secretion of IGFBPs into the effluent was not the result of loss of mucosal barrier integrity. There were no statistically significant differences in protein content of the ostomy fluids in the presence or absence of rejection. Our results suggest that the gastrointestinal IGF axis is altered during some instances of transplanted small bowel rejection, with increased secretion of IGFBPs.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalPediatric Transplantation
Issue number3
StatePublished - Aug 1998


  • Insulin-like growth factor binding proteins
  • Intestines
  • Transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation


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