Transport of yeast vacuolar trehalase to the vacuole.

S. D. Harris, D. A. Cotter

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We have tested yeast secretory mutants, which define different stages of the secretory pathway, for their levels of vacuolar trehalase activity. Mutations that cause accumulation of secretory proteins in the endoplasmic reticulum or in the Golgi body lead to diminished vacuolar trehalase activity. Mutations that cause accumulation of secretory vesicles have no effect on vacuolar trehalase activity. None of the mutations affects cytoplasmic trehalase activity. These results provide further evidence for the existence of a compartmentalized trehalase in yeast, and demonstrate that the enzyme enters the secretory pathway.

Original languageEnglish (US)
Pages (from-to)835-838
Number of pages4
JournalCanadian journal of microbiology
Volume34
Issue number7
DOIs
StatePublished - Jul 1988

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

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