Treatment of adult acute lymphoblastic leukemia with cytosine arabinoside, vincristine, and prednisone

R. D. Gingrich, J. O. Armitage, C. P. Burns

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Thirteen adults with acute lymphoblastic leukemia were entered into a protocol in which cytosine arabinoside infusion was added to vincristine and prednisone as remission induction and periodic intensification therapy. Central nervous system prophylaxis consisting of cranial irradiation and intrathecal methotrexate was given, and all patients received continuous oral 6-mercaptopurine and methotrexate as maintenance treatment. Myelotoxicity was severe during induction, with prolonged granulocyte and platelet count nadirs noted. Nine of 13 patients (69%) obtained a complete remission and one (8%) obtained a partial remission. The median duration of complete remission was 38.1 weeks. It was concluded that cytosine arabinoside in combination with vincristine and prednisone is an effective but toxic antileukemic regimen which did not produce a major improvement in remission duration.

Original languageEnglish (US)
Pages (from-to)1389-1391
Number of pages3
JournalCancer treatment reports
Volume62
Issue number9
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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