Treatment of breast cancer with oral four‐drug chemotherapy

John F. Foley, M. Anne Kessinger, Henry M. Lemon

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Seventy patients with advanced metastatic breast cancer were treated with an oral drug regime of prednisone, cytomel, cytoxan, and methotrexate. One half of the cases (50%) had a response. There were complete remissions in 7%, partial remissions in 27%, and arrests in 16%. The median duration of remissions was 8+ months. There was no significant difference in response between patients with predominant visceral or bone disease nor between pre‐ and post‐menopausal women. One third of non‐hormonally responsive patients responded to this treatment. Side effects consisted predominantly of glucocorticoid change, including cushinoid facies and weight gain. The program was relatively bone marrow sparing. This drug regime is very convenient and safe to give on an outpatient basis.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalJournal of Surgical Oncology
Issue number1
StatePublished - May 1980
Externally publishedYes


  • breast cancer
  • oral chemotherapy

ASJC Scopus subject areas

  • Surgery
  • Oncology


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