Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation

Naoya Kobayashi; Masahiro Ito; Junta Nakamura; Jin Cai; James M. Hammel; Ira J. Fox

doi:10.1177/096368970000900512

Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation

Naoya Kobayashi, Masahiro Ito, Junta Nakamura, Jin Cai, James M. Hammel, Ira J. Fox

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl₄). Intrasplenic transplantation of 50 x 10⁶ primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

Original language	English (US)
Pages (from-to)	671-673
Number of pages	3
Journal	Cell Transplantation
Volume	9
Issue number	5
DOIs	https://doi.org/10.1177/096368970000900512
State	Published - 2000

Keywords

Carbon tetrachloride
Hepatocyte transplantation
Liver cirrhosis
Phenobarbital

ASJC Scopus subject areas

Biomedical Engineering
Cell Biology
Transplantation

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10.1177/096368970000900512

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abstract = "Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.",

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T1 - Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation

AU - Kobayashi, Naoya

AU - Ito, Masahiro

AU - Nakamura, Junta

AU - Cai, Jin

AU - Hammel, James M.

AU - Fox, Ira J.

PY - 2000

Y1 - 2000

N2 - Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

AB - Hepatocyte transplantation (HTx) has been shown to improve the survival of laboratory animals with experimentally induced acute liver failure and to ameliorate the physiologic abnormalities associated with liver-based metabolic deficiencies. However, the role of HTx in the treatment of liver cirrhosis (LC) has not been adequately studied. In order to address this issue, HTx was performed in rats following induction of stable LC using phenobarbital (PhB) and carbon tetrachloride (CCl4). Intrasplenic transplantation of 50 x 106 primary hepatocytes could significantly improve liver functions and prolong the survival of rats with irreversible, decompensated LC.

KW - Carbon tetrachloride

KW - Hepatocyte transplantation

KW - Liver cirrhosis

KW - Phenobarbital

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Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation

Abstract

Keywords

ASJC Scopus subject areas

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