Treatment of early rheumatoid arthritis with minocycline or placebo: Results of a randomized, double-blind, placebo-controlled trial

James R. O'Dell, Claire E. Haire, William Palmer, Walter Drymalski, Steven Wees, Kent Blakely, Melvin Churchill, P. James Eckhoff, Arthur Weaver, Deborah Doud, Nils Erikson, Fred Dietz, Rich Olson, Pierre Maloley, Lynell W. Klassen, Gerald F. Moore

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

Objective. To determine if minocycline is an effective therapy for seropositive rheumatoid arthritis (RA) when used within the first year of disease. Methods. The Rheumatoid Arthritis Investigational Network enrolled 46 patients with RA of <1 year duration into a 6-month study of minocycline (100 mg twice daily) versus placebo. All patients were rheumatoid factor positive. The primary end point of the study was successful completion of 6 months of treatment with no drug toxicity while maintaining 50% improvement in composite symptoms of arthritis. Results. Eighteen of the 46 patients who were enrolled met 50% improvement criteria at 3 months, and maintained at least a 50% improvement for 6 months with no significant drug toxicity. Among them were 15 of the 23 patients (65%) treated with minocycline and 3 of 23 patients (13%) treated with placebo (P < 0.001). Conclusion. In patients with early seropositive RA, therapy with minocycline is superior to placebo.

Original languageEnglish (US)
Pages (from-to)842-848
Number of pages7
JournalArthritis and rheumatism
Volume40
Issue number5
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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    O'Dell, J. R., Haire, C. E., Palmer, W., Drymalski, W., Wees, S., Blakely, K., Churchill, M., James Eckhoff, P., Weaver, A., Doud, D., Erikson, N., Dietz, F., Olson, R., Maloley, P., Klassen, L. W., & Moore, G. F. (1997). Treatment of early rheumatoid arthritis with minocycline or placebo: Results of a randomized, double-blind, placebo-controlled trial. Arthritis and rheumatism, 40(5), 842-848. https://doi.org/10.1002/art.1780400510