Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4

Paul T. Golumbek, Audrey J. Lazenby, Hyam I. Levitsky, Liz M. Jaffee, Hajime Karasuyama, Mitzi Baker, Drew M. Pardoll

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696 Scopus citations

Abstract

The generation of antigen-specific antitumor immunity is the ultimate goal in cancer immunotherapy. When cells from a spontaneously arising murine renal cell tumor were engineered to secrete large doses of interleukin-4 (IL-4) locally, they were rejected in a predominantly T cell-independent manner. However, animals that rejected the IL-4-transfected tumors developed T cell-dependent systemic immunity to the parental tumor. This systemic immunity was tumor-specific and primarily mediated by CD8+ T cells. Established parental tumors could be cured by the systemic immune response generated by injection of the genetically engineered tumors. These results provide a rationale for the use of lymphokine gene-transfected tumor cells as a modality for cancer therapy.

Original languageEnglish (US)
Pages (from-to)713-716
Number of pages4
JournalScience
Volume254
Issue number5032
DOIs
StatePublished - 1991

ASJC Scopus subject areas

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    Golumbek, P. T., Lazenby, A. J., Levitsky, H. I., Jaffee, L. M., Karasuyama, H., Baker, M., & Pardoll, D. M. (1991). Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4. Science, 254(5032), 713-716. https://doi.org/10.1126/science.1948050