Treatment of intraocular pressure elevation after photorefractive keratectomy

Zoltán Zsolt Nagy, Antal Szabó, Ronald R. Krueger, Ildikó Süveges

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Purpose: To study the effect of timolol maleate, dorzolamide, or a combination of both in post photorefractive keratectomy (PRK) eyes with an elevated intraocular pressure (IOP) after topical steroid administration. Setting: Refractive Surgery Outpatient Department, 1st Department of Ophthalmology, Semmelweis University, Budapest, Hungary. Methods: Forty-five patients with elevated IOP were randomly enrolled in 3 groups: Group 1 received timolol maleate 0.5% twice a day; Group 2 received timolol maleate 0.5% twice a day and dorzolamide 2% 3 times a day; and Group 3 received only topical dorzolamide 2% 3 times a day. Intraocular pressure was measured 3 days and 1,3, and 6 weeks after the antiglaucoma medication was started. Results: The mean preoperative IOP was 15.25 mm Hg ± 1.28 (SD). Following administration of topical fluorometholone, the IOP increased a mean of 27.39 ± 2.88 mm Hg. Six weeks after the antiglaucoma therapy was started, the mean IOP reduction was 6.6 mm Hg in Group 1, 8.86 mm Hg in Group 2, and 4.64 mm Hg in Group 3. Conclusions: A combination therapy of timolol 0.5% and dorzolamide 2% was most effective in treating secondary IOP elevation after PRK. Dorzolamide alone did not adequately control secondary post-PRK IOP elevation.

Original languageEnglish (US)
Pages (from-to)1018-1024
Number of pages7
JournalJournal of cataract and refractive surgery
Issue number7
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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