Treatment of Mitomycin-Associated Microangiopathic Hemolytic Anemia With Vincristine

Jean L. Grem, James A. Merritt, Paul P. Carbone

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14 Scopus citations


A syndrome, including microangiopathic hemolytic anemia (MAHA), thrombocytopenia, and renal insufficiency, has been recognized to occur as a complication of antineoplastic therapy with mitomycin. The clinical presentation can vary from a chronic course with mild anemia and slowly progressive renal dysfunction to a fulminant course with severe anemia, rapid deterioration of renal function, and death. The optimal treatment of the mitomycin-associated MAHA syndrome is unknown. Therapy with steroids, antiplatelet agents, and heparin sodium has failed to reverse the MAHA. Plasmapheresis has improved the MAHA in a few patients without reversing the renal failure. We treated two patients who had MAHA and renal dysfunction during chemotherapy that included mitomycin; the MAHA and hypertension both objectively improved after treatment that included vincristine sulfate.

Original languageEnglish (US)
Pages (from-to)566-568
Number of pages3
JournalArchives of Internal Medicine
Issue number3
StatePublished - Mar 1986
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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