Triggered release of antimicrobial peptide from microneedle patches for treatment of wound biofilms

Yajuan Su, Syed Muntazir Andrabi, S. M.Shatil Shahriar, Shannon L. Wong, Guangshun Wang, Jingwei Xie

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Biofilms pose a great challenge for wound management. Herein, this study describes a near-infrared (NIR) light-responsive microneedle patch for on-demand release of antimicrobial peptide for treatment of wound biofilms. IR780 iodide as a photothermal conversion agent and molecularly engineered peptide W379 as an antimicrobial agent are loaded in dissolvable poly(vinylpyrrolidone) (PVP) microneedle patches followed by coating with a phase change material 1-tetradecanol (TD). After placing in an aqueous solution or biofilm containing wounds ex vivo and in vivo, upon exposure to NIR light, the incorporated IR780 induces light-to-heat conversion, causing the melting of TD. This leads to the dissolution of PVP microneedles, enabling the release of loaded W379 peptide from the microneedles into surrounding regions (e.g., solution, biofilm, wound bed). Compared with traditional microneedle patches, NIR light responsive microneedle patches can program the release of antimicrobial peptide and show high antibacterial efficacy in vitro. Meanwhile, this work indicates that NIR light responsive TD-coated, W379-loaded PVP microneedle patches show excellent antibiofilm activities ex vivo and in vivo. Additionally, this microneedle system could be a promising platform for delivering other antimicrobial agents.

Original languageEnglish (US)
Pages (from-to)131-141
Number of pages11
JournalJournal of Controlled Release
StatePublished - Apr 2023


  • Antimicrobial peptide
  • Microneedle patch
  • NIR triggered release
  • Phase changing material coating
  • Wound biofilm

ASJC Scopus subject areas

  • Pharmaceutical Science


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