TY - JOUR
T1 - Triggering receptor expressed on myeloid cells-1 (TREM-1) inhibition in atherosclerosis
AU - Panagopoulos, Anastasios
AU - Samant, Saurabhi
AU - Bakhos, Jules Joel
AU - Liu, Martin
AU - Khan, Behram
AU - Makadia, Janaki
AU - Muhammad, Fayaz
AU - Kievit, Forrest M.
AU - Agrawal, Devendra K.
AU - Chatzizisis, Yiannis S.
N1 - Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/10
Y1 - 2022/10
N2 - Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane protein expressed on endothelial cells, white blood cells, smooth muscle cells and platelets. TREM-1 plays an important role in innate immunity. TREM-1 activation pathways are implicated both in sepsis and in non-infectious inflammatory conditions, including atherosclerosis. TREM-1 enhances the subendothelial lipid accumulation and expression of pro-inflammatory cytokines and matrix-degrading enzymes, thereby promoting inflammation and plaque destabilization. TREM-1 inhibitors attenuate the inflammatory process in the atherosclerotic plaque, leading to plaque stabilization. This review focuses on the role of TREM-1 in the pathophysiology of atherosclerosis and the effects of TREM-1 inhibition in the natural history of the disease.
AB - Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane protein expressed on endothelial cells, white blood cells, smooth muscle cells and platelets. TREM-1 plays an important role in innate immunity. TREM-1 activation pathways are implicated both in sepsis and in non-infectious inflammatory conditions, including atherosclerosis. TREM-1 enhances the subendothelial lipid accumulation and expression of pro-inflammatory cytokines and matrix-degrading enzymes, thereby promoting inflammation and plaque destabilization. TREM-1 inhibitors attenuate the inflammatory process in the atherosclerotic plaque, leading to plaque stabilization. This review focuses on the role of TREM-1 in the pathophysiology of atherosclerosis and the effects of TREM-1 inhibition in the natural history of the disease.
KW - Atherosclerosis
KW - Inflammation
KW - Inhibitors
KW - TREM-1
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U2 - 10.1016/j.pharmthera.2022.108182
DO - 10.1016/j.pharmthera.2022.108182
M3 - Review article
C2 - 35390422
AN - SCOPUS:85127896898
SN - 0163-7258
VL - 238
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
M1 - 108182
ER -