TY - JOUR
T1 - Trisomies 8 and 20 characterize a subgroup of benign fibrous lesions arising in both soft tissue and bone
AU - Bridge, Julia A.
AU - Swarts, Sarah J.
AU - Buresh, Cary
AU - Nelson, Mari
AU - Degenhardt, Joanne M.
AU - Spanier, Suzanne
AU - Maale, Gerhard
AU - Meloni, Aurelia
AU - Lynch, James C.
AU - Neff, James R.
N1 - Funding Information:
Supported by the Nebraska State Department of Health, LB 506 and LB595, and the John A. Wiebe Children's Health Care Fund.
PY - 1999/3
Y1 - 1999/3
N2 - Trisomy 8 and trisomy 20 are nonrandom aberrations in desmoid tumors. The presence of these trisomies in related benign fibrous lesions of bone has not been previously addressed. In this study, 22 specimens from 19 patients diagnosed with desmoid tumor, desmoplastic fibroma, periosteal desmoid tumor, osteofibrous dysplasia, or fibrous dysplasia were examined by cytogenetic analysis of short-term cultures and bi-color fluorescence in situ hybridization of cytological touch preparations or paraffin-embedded tissue with centromeric probes for chromosomes 8 and 20. Trisomy 8 and trisomy 20 were detected by molecular cytogenetic methodologies in 15 specimens, including 10 primary bone lesions. Traditional cytogenetic analysis revealed trisomy 8 in two cases of osteofibrous dysplasia. Our findings demonstrate that trisomy 8 and trisomy 20 are also nonrandom aberrations in histologically similar, but clinically distinct, benign fibrous lesions of bone.
AB - Trisomy 8 and trisomy 20 are nonrandom aberrations in desmoid tumors. The presence of these trisomies in related benign fibrous lesions of bone has not been previously addressed. In this study, 22 specimens from 19 patients diagnosed with desmoid tumor, desmoplastic fibroma, periosteal desmoid tumor, osteofibrous dysplasia, or fibrous dysplasia were examined by cytogenetic analysis of short-term cultures and bi-color fluorescence in situ hybridization of cytological touch preparations or paraffin-embedded tissue with centromeric probes for chromosomes 8 and 20. Trisomy 8 and trisomy 20 were detected by molecular cytogenetic methodologies in 15 specimens, including 10 primary bone lesions. Traditional cytogenetic analysis revealed trisomy 8 in two cases of osteofibrous dysplasia. Our findings demonstrate that trisomy 8 and trisomy 20 are also nonrandom aberrations in histologically similar, but clinically distinct, benign fibrous lesions of bone.
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U2 - 10.1016/S0002-9440(10)65319-9
DO - 10.1016/S0002-9440(10)65319-9
M3 - Article
C2 - 10079250
AN - SCOPUS:0032997840
SN - 0002-9440
VL - 154
SP - 729
EP - 733
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 3
ER -