Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma

Paul L. Crispen, Yuri Sheinin, Timothy J. Roth, Christine M. Lohse, Susan M. Kuntz, Xavier Frigola, R. Houston Thompson, Stephen A. Boorjian, Haidong Dong, Bradley C. Leibovich, Michael L. Blute, Eugene D. Kwon

Research output: Contribution to journalArticlepeer-review

175 Scopus citations

Abstract

Purpose: Although the prognostic value of B7-H1 and B7-H4 expression by tumor cells in clear cell renal cell carcinoma (ccRCC) has been established, the role of B7-H3 is unknown. As such, we evaluated the association of B7-H3 expression with clinicopathologic outcomes in patients treated for ccRCC. Experimental Design: Nephrectomy specimens from 743 consecutive patients treated for ccRCC at our institution from 1990 to 1999 were evaluated for B7-H3 expression by immunohis-tochemical staining. Associations of B7-H 3 expression with clinical and pathologic features were evaluated using x2 and Fisher's exact tests. Associations of B7-H3 expression with death from RCC were evaluated using Cox proportional hazards regression models. Results: B7-H3 expression by tumor cells or tumor vasculature was noted in 17% and 95% of specimens, respectively. The presence of either tumor cell or diffuse tumor vasculature expression of B7-H3 was present in 46% of specimens and was associated with multiple adverse clinical and pathologic features. After multivariable adjustment, the presence of either tumor cell or diffuse tumor vasculature B7-H3 expression was significantly associated with an increased risk of death from RCC (risk ratio, 1.38; 95% confidence interval, 1.03-1.84; P = 0.029). Conclusions: Both tumor cell and tumor vasculature B7-H3 expression convey important information to predict ccRCC outcomes. Collectively, our past and present studies pertaining to B7-H ligand expression indicate that ccRCC may use redundant mechanisms to compromise host antitumoral immunity. Future studies will focus on the effect of combined B7-H ligand expression in RCC.

Original languageEnglish (US)
Pages (from-to)5150-5157
Number of pages8
JournalClinical Cancer Research
Volume14
Issue number16
DOIs
StatePublished - Aug 15 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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