Tumor immuno-environment in cancer progression and therapy

Pawel Kalinski, James E. Talmadge

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The approvals of Provenge (Sipuleucel-T), Ipilimumab (Yervoy/anti-CTLA-4) and blockers of the PD-1 - PD-L1/PD-L2 pathway, such as nivolumab (Opdivo), pembrolizumab (Keytruda), or atezolizumab (Tecentriq), have established immunotherapy as a key component of comprehensive cancer care. Further, murine mechanistic studies and studies in immunocompromised patients have documented the critical role of immunity in effectiveness of radio- and chemotherapy. However, in addition to the ability of the immune system to control cancer progression, it can also promote tumor growth, via regulatory T cells (Tregs), myeloid-derived dendritic cells (MDSCs) and tumor associated macrophages (TAM), which can enhance survival of cancer cells directly or via the regulation of the tumor stroma. An increasing body of evidence supports a central role for the tumor microenvironment (TME) and the interactions between tumor stroma, infiltrating immune cells and cancer cells during the induction and effector phase of anti-cancer immunity, and the overall effectiveness of immunotherapy and other forms of cancer treatment. In this chapter, we discuss the roles of key TME components during tumor progression, metastatic process and cancer therapy-induced tumor regression, as well as opportunities for their modulation to enhance the overall therapeutic benefit.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages1-18
Number of pages18
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1036
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Adoptive cell therapies
  • Cancer
  • Checkpoint blockade
  • Immunotherapy
  • Tumor microenvironment
  • Vaccines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Tumor immuno-environment in cancer progression and therapy'. Together they form a unique fingerprint.

  • Cite this

    Kalinski, P., & Talmadge, J. E. (2017). Tumor immuno-environment in cancer progression and therapy. In Advances in Experimental Medicine and Biology (pp. 1-18). (Advances in Experimental Medicine and Biology; Vol. 1036). Springer New York LLC. https://doi.org/10.1007/978-3-319-67577-0_1