Tumor Microenvironment-Responsive Polymeric iRGD and Doxorubicin Conjugates Reduce Spontaneous Lung Metastasis in an Orthotopic Breast Cancer Model

Zheng Hong Peng, Chinmay M. Jogdeo, Jing Li, Ying Xie, Yazhe Wang, Yuri Sheinin, Jindřich Kopeček, David Oupický

Research output: Contribution to journalArticlepeer-review

Abstract

Tremendous progress has been made in the field of nanomedicine for cancer treatment. However, most of the research to date has been focused on inhibiting primary tumor growth with comparatively less efforts directed towards managing tumor metastasis. Here, we introduce a polymeric conjugate P-DOX-iRGD that not only significantly suppressed primary tumor growth but also substantially inhibited pulmonary metastasis in an orthotopic mouse model of breast cancer. In addition, treatment with P-DOX-iRGD markedly reduced breast cancer-induced splenomegaly and liver hematopoiesis. Interestingly, contrasting results were seen for the free form and polymeric form of DOX in vitro and in vivo, which may be attributed to the enhanced permeability and retention (EPR) effect.

Original languageEnglish (US)
Article number1725
JournalPharmaceutics
Volume14
Issue number8
DOIs
StatePublished - Aug 2022

Keywords

  • breast cancer
  • cancer metastasis
  • doxorubicin
  • hematopoiesis
  • iRGD
  • splenomegaly

ASJC Scopus subject areas

  • Pharmaceutical Science

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