Tumor necrosis factor enhances susceptibility of vascular endothelial cells to neutrophil-mediated killing

J. Varani, M. J. Bendelow, D. E. Sealey, S. L. Kunkel, D. E. Gannon, U. S. Ryan, P. A. Ward

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Tumor necrosis factor has a variety of effects on different types of cells in vitro, including endothelial cells. The current studies show that pretreatment of rat pulmonary artery endothelial cells with tumor necrosis factor increases in a time- and dose-dependent manner their sensitivity to killing by neutrophils stimulated with phorbol myristate acetate or C5a. Similar effects are seen with interleukin-1. These data suggest that tumor necrosis factor and interleukin-1 may have important pro-inflammatory effects on endothelial cells.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalLaboratory Investigation
Volume59
Issue number2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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