Tumor targeting by intra-arterial infusion of 5-[123I]iodo-2′-deoxyuridine in patients with liver metastases from colorectal cancer

Giuliano Mariani, Sonia Di Sacco, Duccio Volterrani, Lorella Di Luca, Simona Buralli, Rossella Di Stefano, Janina Baranowska-Kortylewicz, Danilo Bonora, Federica Matteucci, Sergio Ricci, C. Riccardo Bellina, Alfredo Falcone, Piero A. Salvadori, Franco Mosca, S. J. Adelstein, Amin I. Kassis

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33 Scopus citations

Abstract

We previously showed the tumor-targeting potential of the 125I-labeled thymidine analog 5-iodo-2′-deoxyuridine (IUdR) injected intratumorally in patients with high tumor-cell kinetics. In this study, we evaluated the tumor incorporation of [123I]IUdR infused intra-arterially in patients with liver metastases from colorectal cancer. Methods: Iodine-123-IUdR (110-300 MBq, 3-8 mCi, specific activity, 150-200 Ci/μmole) was infused into the hepatic artery of 16 patients with inoperable liver metastases over 30-45 min through a permanent intra-arterial catheter. A dynamic sequence during infusion, spot images, whole-body scans and SPECT acquisitions were recorded up to 42 hr. Blood and urine samples were obtained for biodistribution and HPLC analyses. Results: In the 14 patients with adequate tumor perfusion patterns, tumor uptake reached 2%-17.6% ID at the end of infusion. After a washout phase that lasted 18-20 hr, incorporated radioactivity remained steadily associated with the tumor lesions until at least 42 hr after infusion (about 1.4%-11.1% ID). HPLC analysis indicated a virtually 100% first-pass hepatic deiodination of unincorporated [123I]IUdR (about 80%-95% ID recovered in the 42-hr urine). No significant uptake was detected in the bone marrow or in other normal dividing tissues. Conclusion: These results encourage further studies to enable dosimetric estimates, optimization of dose regimens, and examination of the therapeutic potential of Auger-electron-emitter-labeled IUdR in cancer therapy utilizing this type of approach.

Original languageEnglish (US)
Pages (from-to)22S-25S
JournalJournal of Nuclear Medicine
Volume37
Issue number4 SUPPL.
StatePublished - Apr 1996

Keywords

  • Colorectal cancer
  • Intra-arterial infusion
  • Iodine-123-IUdR
  • Liver metastases
  • Locoregional administration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Mariani, G., Di Sacco, S., Volterrani, D., Di Luca, L., Buralli, S., Di Stefano, R., Baranowska-Kortylewicz, J., Bonora, D., Matteucci, F., Ricci, S., Riccardo Bellina, C., Falcone, A., Salvadori, P. A., Mosca, F., Adelstein, S. J., & Kassis, A. I. (1996). Tumor targeting by intra-arterial infusion of 5-[123I]iodo-2′-deoxyuridine in patients with liver metastases from colorectal cancer. Journal of Nuclear Medicine, 37(4 SUPPL.), 22S-25S.