Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer

Annick D. Van Den Abbeele, Ronald F. Tutrone, Robert M. Berman, Janina Baranowska-Kortylewicz, Paul D. Barclay, Jerome P. Richie, S. James Adelstein, Amin I. Kassis

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Since bladder cancer arises in the superficial lining of the urothelium, it is a likely candidate for site-directed administration of 5-iodo-2'- deoxyuridine radiolabeled with the Auger electron emitter 123I or 125I (*IUdR). Methods: We instilled *IUdR for 2 hr directly within the bladder lumen of rats bearing N-methyl-N-nitrosourea (NMU)-induced bladder cancer and conducted scintigraphic, biodistribution and autoradiography (ARG) studies 48 hr and 1 wk later. Control animals were not subjected to the carcinogen but were instilled with *IUdR. Results: Two groups of animals were identified after instillation of MNU: Group A consisted of rats with hyperplasia and Group B of rats with papillary carcinoma (stages Ta and T1). Scintigraphic detection of carcinomas was achieved with high sensitivity and specificity, and increased tumor-to-normal tissue ratios were obtained in both groups. Moreover, ARG demonstrated that (1) the uptake of *IUdR was observed in the hyperplastic and carcinomatous urothelium but not in the normal urothelium; (2) uptake was detected at a very early stage of tumor development (hyperplasia stage); (3) *IUdR was able to penetrate deep within the bladder wall; and (4) other normal dividing tissues, such as the bone marrow, the small intestine and the large intestine, were free of silver grains (i.e., no DNA-incorporated *IUdR). Conclusion: Since this carrier of Auger electron emitters has antineoplastic effects ([123I]IUdR and [125I]IUdR) in addition to its scintigraphic potential ([123I]IUdR and [131I]IUdR), it holds promise for therapy and early diagnosis of bladder cancer.

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalJournal of Nuclear Medicine
Volume37
Issue number2
StatePublished - Feb 1996

Keywords

  • 5-iodo-2'-deoxyuridine
  • Auger electron emitters
  • bladder cancer
  • radioiodine

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Van Den Abbeele, A. D., Tutrone, R. F., Berman, R. M., Baranowska-Kortylewicz, J., Barclay, P. D., Richie, J. P., Adelstein, S. J., & Kassis, A. I. (1996). Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer. Journal of Nuclear Medicine, 37(2), 315-320.