Tumor‐associated neutrophils in cancer: Going pro

Lingyun Wu, Sugandha Saxena, Mohammad Awaji, Rakesh K. Singh

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The progression of cancer is not only about the tumor cell itself, but also about other involved players including cancer cell recruited immune cells, their released pro‐inflammatory factors, and the extracellular matrix. These players constitute the tumor microenvironment and play vital roles in the cancer progression. Neutrophils—the most abundant white blood cells in the circulation system—constitute a significant part of the tumor microenvironment. Neutrophils play major roles linking inflammation and cancer and are actively involved in progression and metastasis. Additionally, recent data suggest that neutrophils could be considered one of the emerging targets for multiple cancer types. This review summarizes the most recent updates regarding neutrophil recruitments and functions in the tumor microenvironment as well as potential development of neutrophils‐targeted putative therapeutic strategies.

Original languageEnglish (US)
Article number564
JournalCancers
Volume11
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • Cancer metastasis
  • Neutrophil extracellular traps
  • Neutrophil polarization
  • Neutrophils

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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