Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell Carcinoma

Jue Wang, Geoffrey A. Talmon, Michael Feloney, Michael C. Morris

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy.Patients and Methods: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patinet subsequently had multiple tumor recurrences.Results: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis.Conclusion: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.

Original languageEnglish (US)
Article number155
JournalWorld Journal of Surgical Oncology
StatePublished - Nov 28 2011


  • Metastasectomy
  • Metastatic disease
  • Recurrence
  • Renal cell carcinoma (rcc)

ASJC Scopus subject areas

  • Surgery
  • Oncology


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