Twisting electrospun nanofiber fine strips into functional sutures for sustained co-delivery of gentamicin and silver

Shixuan Chen, Liangpeng Ge, Aubrey Mueller, Mark A. Carlson, Matthew J. Teusink, Franklin D. Shuler, Jingwei Xie

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Surgical site infections (SSIs) represent the most common nosocomial infection among surgical patients. In order to prevent SSIs in a sustained manner and lessen side effects, we developed a twisting method for generation of nanofiber-based sutures capable of simultaneous delivery of silver and gentamicin. The prepared sutures are composed of core-sheath nanofibers with gentamicin/pluronic F127 in the core and silver/PCL in the sheath produced by co-axial electrospinning. The diameters of obtained sutures range from ~80 μm to ~1.2 mm. The in vitro release profiles of silver and gentamicin exhibit an initial burst followed by a sustained release over 5 weeks. The co-encapsulated sutures were able to kill bacteria much more effectively than gentamicin or silver alone loaded nanofiber sutures, without showing obvious impact on proliferation and migration of dermal fibroblasts and keratinocytes. The gentamicin and silver co-loaded PCL nanofiber sutures may hold great potential for prevention of SSIs.

Original languageEnglish (US)
Pages (from-to)1435-1445
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume13
Issue number4
DOIs
StatePublished - May 1 2017

Keywords

  • Anti-bacterial
  • Co-delivery
  • Electrospun nanofibers
  • Surgical site infections
  • Suture

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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