TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits

Dorothée Diogo, Lisa Bastarache, Katherine P. Liao, Robert R. Graham, Robert S. Fulton, Jeffrey D. Greenberg, Steve Eyre, John Bowes, Jing Cui, Annette Lee, Dimitrios A. Pappas, Joel M. Kremer, Anne Barton, Marieke J.H. Coenen, Barbara Franke, Lambertus A. Kiemeney, Xavier Mariette, Corrine Richard-Miceli, Helena Canhão, João E. FonsecaNiek De Vries, Paul P. Tak, J. Bart A. Crusius, Michael T. Nurmohamed, Fina Kurreeman, Ted R. Mikuls, Yukinori Okada, Eli A. Stahl, David E. Larson, Tracie L. Deluca, Michelle O'Laughlin, Catrina C. Fronick, Lucinda L. Fulton, Roman Kosoy, Michael Ransom, Tushar R. Bhangale, Ward Ortmann, Andrew Cagan, Vivian Gainer, Elizabeth W. Karlson, Isaac Kohane, Shawn N. Murphy, Javier Martin, Alexandra Zhernakova, Lars Klareskog, Leonid Padyukov, Jane Worthington, Elaine R. Mardis, Michael F. Seldin, Peter K. Gregersen, Timothy Behrens, Soumya Raychaudhuri, Joshua C. Denny, Robert M. Plenge

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Immunology and Microbiology

Biochemistry, Genetics and Molecular Biology

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