Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer

Bernhard C. Pestalozzi, George A. Sotos, Peter L. Choyke, Jason S. Fisherman, Kenneth H. Cowan, Joyce A. O'Shaughnessy

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Background. Typhlitis is being recognized with increasing frequency as a serious complication of aggressive chemotherapy for hematologic and solid malignancies. Methods. In this report the authors describe two cases of typhlitis in patients with metastatic breast cancer treated with taxol and doxorubicin. Results. Both cases occurred during the first cycle of treatment with taxol (180 mg/m2) and doxorubicin (75 mg/m2), being given simultaneously as 72‐hour continuous intravenous infusions. Conclusion. Two cases of typhlitis have occurred after combined treatment with taxol and doxorubicin, while typhlitis has not been described after treatment with either drug alone.

Original languageEnglish (US)
Pages (from-to)1797-1800
Number of pages4
JournalCancer
Volume71
Issue number5
DOIs
StatePublished - Mar 1 1993

Keywords

  • doxorubicin
  • metastatic breast cancer
  • taxol
  • typhlitis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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