Ultra-compliant thermal AFM probes for studying of cellular properties

King Wai Chiu Lai, Angelo Gaitas, Ruiguo Yang, Carmen Kar Man Fung, Ning Xi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Atomic force microscopy (AFM) can be used for a number of nanoscale biological studies. It opens the possibility to monitor cellular processes in physiological conditions with the ability to perform high resolution imaging and force measurements. However, analysis of the mechanical property of the living cells is difficult and the sensitivity is low. Conventional AFM probes use high-stiffness materials and therefore, it makes the force measurement on soft samples becoming more difficult. In this work an ultra-compliant AFM probe made of polyimide was used to provide an improved imaging and force measurement of cancer cells. The probe includes an embedded sensing element for thermal conductance characterization. The probe was used for thermal conductance and topographical mapping of biological cells. The probe allows for high speed imaging of cells in liquids.

Original languageEnglish (US)
Title of host publication2010 10th IEEE Conference on Nanotechnology, NANO 2010
Pages369-372
Number of pages4
DOIs
StatePublished - 2010
Externally publishedYes
Event2010 10th IEEE Conference on Nanotechnology, NANO 2010 - Ilsan, Gyeonggi-Do, Korea, Republic of
Duration: Aug 17 2010Aug 20 2010

Publication series

Name2010 10th IEEE Conference on Nanotechnology, NANO 2010

Other

Other2010 10th IEEE Conference on Nanotechnology, NANO 2010
Country/TerritoryKorea, Republic of
CityIlsan, Gyeonggi-Do
Period8/17/108/20/10

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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