Abstract
This study was designed to determine if microencapsulated tetracaine would provide a longer duration of local anesthesia than nonmicroencapsulated (neat) tetracaine. Local anesthesia was determined by monitoring the response of the rat to tail clamping after the installation of a subcutaneous ring block. Ten percent microencapsulated tetracaine was found to provide local anesthesia of the tail for a 43‐hour duration. Ten percent tetracaine solution was toxic. One percent tetracaine solution provided a tail block lasting 8 hours. Lecithin membranes without drug provided no block. This study demonstrates that lecithin‐coated tetracaine microcrystals produce a local anesthetic effect that is ultra‐long in duration, reversible, and not systemically toxic. 1994 American College of Clinical Pharmacology
Original language | English (US) |
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Pages (from-to) | 699-702 |
Number of pages | 4 |
Journal | The Journal of Clinical Pharmacology |
Volume | 34 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1994 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)