Abstract
Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.
Original language | English (US) |
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Pages (from-to) | 748-756 |
Number of pages | 9 |
Journal | JACC: Basic to Translational Science |
Volume | 2 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2017 |
Keywords
- N (ω)-nitro-L-arginine methyl ester
- catheter-induced vasospasm
- microbubble
- ultrasound
- velocity time integral
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine