Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm

Shelby Kutty, Na Liu, Jia Zhou, Yunbin Xiao, Juefei Wu, David A. Danford, John Lof, Feng Xie, Thomas R. Porter

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.

Original languageEnglish (US)
Pages (from-to)748-756
Number of pages9
JournalJACC: Basic to Translational Science
Volume2
Issue number6
DOIs
StatePublished - Dec 2017

Keywords

  • N (ω)-nitro-L-arginine methyl ester
  • catheter-induced vasospasm
  • microbubble
  • ultrasound
  • velocity time integral

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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