6 Scopus citations


Alveolar macrophages recovered by bronchoalveolar lavage from 14 heavy smokers with chronic bronchitis were assessed. Ultrastructural examination revealed marked cellular heterogeneity. Three subpopulations of alveolar macrophages were readily identifiable. These have been termed "young," "mature," and "degrading," reflecting their ultrastructural features. In addition, a majority of the cells were found to be positive by TUNEL staining, indicating DNA damage, but a very small percentage tested positive for Caspase-3, suggesting that apoptosis might not account for the DNA damage in at least some of these cells. A small percentage of proliferating cells were noted.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalUltrastructural Pathology
Issue number1
StatePublished - 2001


  • Alveolar macrophage
  • Apoptosis
  • Bronchoalveolar lavage
  • Chronic bronchitis
  • Proliferation
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology


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