Unconventional secretion of Ebola virus matrix protein VP40

Olivier Reynard, St Patrick Reid, Audrey Page, Mathieu Mateo, Nathalie Alazard-Dany, Hervé Raoul, Christopher F. Basler, Viktor E. Volchkov

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The Ebola virus matrix protein VP40 plays an essential role in virus assembly and budding. In this study we reveal that transient VP40 expression results in the release into the culture medium of substantial amounts of soluble monomeric VP40 in addition to the release of virus-like particles containing an oligomeric form of this protein as previously described. We show that VP40 secretion is endoplasmic reticulum/Golgi-independent and is not associated with cell death. Soluble VP40 was observed during Ebola virus infection of cells and was also found in the serum of virus-infected animals albeit in lower amounts. Unconventional secretion of VP40 may therefore play a role in Ebola virus pathogenicity.

Original languageEnglish (US)
Pages (from-to)S833-S839
JournalJournal of Infectious Diseases
Volume204
Issue numberSUPPL. 3
DOIs
StatePublished - Nov 1 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Reynard, O., Reid, S. P., Page, A., Mateo, M., Alazard-Dany, N., Raoul, H., Basler, C. F., & Volchkov, V. E. (2011). Unconventional secretion of Ebola virus matrix protein VP40. Journal of Infectious Diseases, 204(SUPPL. 3), S833-S839. https://doi.org/10.1093/infdis/jir305