@article{8ae297790c7b440dab872ab017d1b16e,
title = "Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes",
abstract = "Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure. This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes.",
keywords = "Biomarkers, Collagen, Extracellular matrix, Matrix metalloproteinases, Myocardial infarction",
author = "Nielsen, {Signe Holm} and Mouton, {Alan J.} and DeLeon-Pennell, {Kristine Y.} and Federica Genovese and Morten Karsdal and Lindsey, {Merry L.}",
note = "Funding Information: We would like to thank past and present members of the Lindsey lab for their contributions to this knowledge. We acknowledge grant support from The Danish Research Foundation and the National Institute of Health HL075360 , HL129823 , HL051971 , GM104357 , GM114833 , and GM115428 , and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award 5I01BX000505 and IK2BX003922 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the Danish Research Foundation, the National Institutes of Health, or the Veterans Administration. Funding Information: We would like to thank past and present members of the Lindsey lab for their contributions to this knowledge. We acknowledge grant support from The Danish Research Foundation and the National Institute of Health HL075360, HL129823, HL051971, GM104357, GM114833, and GM115428, and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Award 5I01BX000505 and IK2BX003922. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Danish Research Foundation, the National Institutes of Health, or the Veterans Administration. Publisher Copyright: {\textcopyright} 2017 International Society of Matrix Biology",
year = "2019",
month = jan,
doi = "10.1016/j.matbio.2017.12.001",
language = "English (US)",
volume = "75-76",
pages = "43--57",
journal = "Matrix Biology",
issn = "0945-053X",
publisher = "Elsevier",
}