Understanding the mechanisms that determine extracellular matrix remodeling in the infarcted myocardium

Mavis A.A. Tenkorang, Upendra Chalise, Michael J. Daseke, Shelby R. Konfrst, Merry L. Lindsey

Research output: Contribution to journalReview articlepeer-review

Abstract

Myocardial Infarction (MI) initiates a series of wound healing events that begins with up-regulation of an inflammatory response and culminates in scar formation. The extracellular matrix (ECM) is intricately involved in all stages from initial break down of existing ECM to synthesis of new ECM to form the scar. This review will summarize our current knowledge on the processes involved in ECM remodeling after MI and identify the gaps that still need to be filled.

Original languageEnglish (US)
Pages (from-to)1679-1687
Number of pages9
JournalBiochemical Society Transactions
Volume47
Issue number6
DOIs
StatePublished - Nov 14 2019

ASJC Scopus subject areas

  • Biochemistry

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