Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

Dawn M. Jelley-Gibbs, Deborah M. Brown, John P. Dibble, Laura Haynes, Sheri M. Eaton, Susan L. Swain

Research output: Contribution to journalArticlepeer-review

209 Scopus citations


The kinetics of presentation of influenza virus-derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3-4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained. JEM

Original languageEnglish (US)
Pages (from-to)697-706
Number of pages10
JournalJournal of Experimental Medicine
Issue number5
StatePublished - Sep 5 2005
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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