Universal automated high frequency oscillation detector for real-time, long term EEG

Stephen V. Gliske, Zachary T. Irwin, Kathryn A. Davis, Kinshuk Sahaya, Cynthia Chestek, William C. Stacey

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Objective: Interictal high frequency oscillations (HFOs) in intracranial EEG are a potential biomarker of epilepsy, but current automated HFO detectors require human review to remove artifacts. Our objective is to automatically redact false HFO detections, facilitating clinical use of interictal HFOs. Methods: Intracranial EEG data from 23 patients were processed with automated detectors of HFOs and artifacts. HFOs not concurrent with artifacts were labeled quality HFOs (qHFOs). Methods were validated by human review on a subset of 2000 events. The correlation of qHFO rates with the seizure onset zone (SOZ) was assessed via (1) a retrospective asymmetry measure and (2) a novel quasi-prospective algorithm to identify SOZ. Results: Human review estimated that less than 12% of qHFOs are artifacts, whereas 78.5% of redacted HFOs are artifacts. The qHFO rate was more correlated with SOZ (p = 0.020, Wilcoxon signed rank test) and resected volume (p = 0.0037) than baseline detections. Using qHFOs, our algorithm was able to determine SOZ in 60% of the ILAE Class I patients, with all algorithmically-determined SOZs fully within the resected volumes. Conclusions: The algorithm reduced false-positive HFO detections, improving the precision of the HFO-biomarker. Significance: These methods provide a feasible strategy for HFO detection in real-time, continuous EEG with minimal human monitoring of data quality.

Original languageEnglish (US)
Pages (from-to)1057-1066
Number of pages10
JournalClinical Neurophysiology
Volume127
Issue number2
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • Artifact detector
  • Automated detector
  • High frequency oscillation
  • Ripple
  • Seizure onset zone

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Fingerprint

Dive into the research topics of 'Universal automated high frequency oscillation detector for real-time, long term EEG'. Together they form a unique fingerprint.

Cite this