Abstract
In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.
Original language | English (US) |
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Pages (from-to) | 666-667 |
Number of pages | 2 |
Journal | Chemistry and Biology |
Volume | 19 |
Issue number | 6 |
DOIs | |
State | Published - Jun 22 2012 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Drug Discovery
- Clinical Biochemistry