Unleashing a "true" pSer-mimic in the cell

Kaushik Panigrahi, David L. Nelson, David B. Berkowitz

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

In this issue of Chemistry & Biology, Arrendale and coworkers demonstrate a new prodrug strategy for intracellular delivery of an α, α-(difluoromethylene)phosphonate phosphoserine mimic. The deprotected pseudo-phosphopeptide releases the pro-apoptotic FOXO3a-transcription factor from its 14-3-3-adaptor protein complex, resulting in leukemic cell death.

Original languageEnglish (US)
Pages (from-to)666-667
Number of pages2
JournalChemistry and Biology
Volume19
Issue number6
DOIs
StatePublished - Jun 22 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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