Abstract
Resistance to antineoplastic drugs may develop through a variety of mechanisms, including deletion of membrane-transport mechanisms, an increase in target-enzyme concentration, or a deletion of an essential drug-activating enzyme. One unique mechanism for mutation to drug resistance is amplification of the gene coding for a target protein, leading to elevated levels of the protein. In studies of cultured experimental tumor-cell lines, resistance to a variety of toxic substances, including cadmium1 and the antineoplastic drugs N-phosphonacetyl-L-aspartate2 and methotrexate,3 has been ascribed to gene amplification. The process of gene amplification in methotrexate-resistant mammalian cells may occur within a single chromosome, producing an.
Original language | English (US) |
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Pages (from-to) | 199-202 |
Number of pages | 4 |
Journal | New England Journal of Medicine |
Volume | 308 |
Issue number | 4 |
DOIs | |
State | Published - Jan 27 1983 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine