TY - JOUR
T1 - Up-regulation of Soluble Tumor Necrosis Factor Receptor Two in Plasma of HIV-Seropositive Individuals Who Use Opiates
AU - Ryan, Lisa A.
AU - Brester, Michelle
AU - Bohac, Daryl
AU - Morgello, Susan
AU - Zheng, Jialin
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/1
Y1 - 2004/1
N2 - Previously, we reported an increase in soluble tumor necrosis factor-alpha receptor two (sTNF-R2) and soluble CD14 (sCD14) in the plasma of HFV-seropositive individuals with neurocognitive dysfunction compared to their cognitively intact counterparts. As intravenous drug use is not only a risk factor for HFV but also an immunomodulator, we sought to examine the effects of drug use on soluble markers of immune activation. These relationships were investigated in 25 patients with late stage HIV-1 disease. TNF-α, sTNF-R1, sTNF-R2, and sCD14 were measured in patient plasma. These values were correlated with drug use and neurocognitive function. sTNF-R2 was significantly up-regulated in those patients who used opiates compared to those who did not. There was no difference in TNF-α, sTNF-R1, or sCD14 between the groups. Further, there was no connection between opiate use and neurocognitive dysfunction.
AB - Previously, we reported an increase in soluble tumor necrosis factor-alpha receptor two (sTNF-R2) and soluble CD14 (sCD14) in the plasma of HFV-seropositive individuals with neurocognitive dysfunction compared to their cognitively intact counterparts. As intravenous drug use is not only a risk factor for HFV but also an immunomodulator, we sought to examine the effects of drug use on soluble markers of immune activation. These relationships were investigated in 25 patients with late stage HIV-1 disease. TNF-α, sTNF-R1, sTNF-R2, and sCD14 were measured in patient plasma. These values were correlated with drug use and neurocognitive function. sTNF-R2 was significantly up-regulated in those patients who used opiates compared to those who did not. There was no difference in TNF-α, sTNF-R1, or sCD14 between the groups. Further, there was no connection between opiate use and neurocognitive dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=0742307441&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0742307441&partnerID=8YFLogxK
U2 - 10.1089/088922204322749486
DO - 10.1089/088922204322749486
M3 - Article
C2 - 15000697
AN - SCOPUS:0742307441
SN - 0889-2229
VL - 20
SP - 41
EP - 45
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 1
ER -