Updated full range of Eliciting Dose values for Cow's milk for use in food allergen risk assessment

W. Marty Blom, Joost Westerhout, Joseph L. Baumert, Marie Y. Meima, Paul J. Turner, Motohiro Ebisawa, Noriyuki Yanagida, Benjamin C. Remington, Geert F. Houben

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Access to Eliciting Doses (ED) for allergens enables advanced food allergen risk assessment. Previously, the full ED range for 14 allergenic foods, including milk, and recommendations for their use were provided (Houben et al., 2020). Additional food challenge studies with cow's milk-allergic patients added 247 data points to the original dataset. Using the Stacked Model Averaging statistical method for interval-censored data on the 697 individual NOAELs and LOAELs for milk generated an updated full ED distribution. The ED01 and ED05, the doses at which 1% and 5% of the milk-allergic population would be predicted to experience any objective allergic reaction, were 0.3 and 3.2 mg milk protein for the discrete and 0.4 mg and 4.3 mg milk protein for the cumulative dose distribution, respectively. These values are slightly higher but remain within the 95% confidence interval of previously published EDs. We recommend using the updated EDs for future characterization of risks of exposure of milk-allergic individuals to milk protein. This paper contributes to the discussion on the Reference Dose for milk in the recent Ad hoc Joint FAO/WHO Expert Consultation on Risk Assessment of Food Allergens. It will also benefit harmonization of food allergen risk assessment and risk management globally.

Original languageEnglish (US)
Article number113381
JournalFood and Chemical Toxicology
Volume168
DOIs
StatePublished - Oct 2022

Keywords

  • Allergenic food
  • Eliciting Dose
  • Food allergen
  • Food allergy
  • Risk assessment
  • Risk management

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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