Uptake of diethylcarbamazine by microfilariae and adults of Litomosoides carinii and Dipetalonema viteae

V. M.L. Srivastavat; D. P. Singh; R. K. Chatterjee; A. B. Sen

doi:10.1017/S0022149X0002695X

Uptake of diethylcarbamazine by microfilariae and adults of Litomosoides carinii and Dipetalonema viteae

V. M.L. Srivastavat, D. P. Singh, R. K. Chatterjee, A. B. Sen

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Microfilariae of Litomosoides carinii and Dipetalonema viteae absorbed about ten times as much diethylcarbamazine (DEC) as did their adults, but bound much less. The higher uptake of DEC by the microfilariae might be related to the fact that DEC is microfilaricidal. Binding of DEC with the parasii supports the view that the microfilaricidal action begins with the fixation of the drug to the microfilariae.

Original language	English (US)
Pages (from-to)	197-199
Number of pages	3
Journal	Journal of Helminthology
Volume	58
Issue number	3
DOIs	https://doi.org/10.1017/S0022149X0002695X
State	Published - Sep 1984
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Animal Science and Zoology

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10.1017/S0022149X0002695X

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title = "Uptake of diethylcarbamazine by microfilariae and adults of Litomosoides carinii and Dipetalonema viteae",

abstract = "Microfilariae of Litomosoides carinii and Dipetalonema viteae absorbed about ten times as much diethylcarbamazine (DEC) as did their adults, but bound much less. The higher uptake of DEC by the microfilariae might be related to the fact that DEC is microfilaricidal. Binding of DEC with the parasii supports the view that the microfilaricidal action begins with the fixation of the drug to the microfilariae.",

author = "Srivastavat, {V. M.L.} and Singh, {D. P.} and Chatterjee, {R. K.} and Sen, {A. B.}",

note = "Funding Information: ACKNOWLEDGEMENT One of the authors (DPS) is grateful to the Indian Council of Medical Research, New Delhi for the award of a Junior Research Fellowship.",

year = "1984",

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doi = "10.1017/S0022149X0002695X",

language = "English (US)",

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T1 - Uptake of diethylcarbamazine by microfilariae and adults of Litomosoides carinii and Dipetalonema viteae

AU - Srivastavat, V. M.L.

AU - Singh, D. P.

AU - Chatterjee, R. K.

AU - Sen, A. B.

N1 - Funding Information: ACKNOWLEDGEMENT One of the authors (DPS) is grateful to the Indian Council of Medical Research, New Delhi for the award of a Junior Research Fellowship.

PY - 1984/9

Y1 - 1984/9

N2 - Microfilariae of Litomosoides carinii and Dipetalonema viteae absorbed about ten times as much diethylcarbamazine (DEC) as did their adults, but bound much less. The higher uptake of DEC by the microfilariae might be related to the fact that DEC is microfilaricidal. Binding of DEC with the parasii supports the view that the microfilaricidal action begins with the fixation of the drug to the microfilariae.

AB - Microfilariae of Litomosoides carinii and Dipetalonema viteae absorbed about ten times as much diethylcarbamazine (DEC) as did their adults, but bound much less. The higher uptake of DEC by the microfilariae might be related to the fact that DEC is microfilaricidal. Binding of DEC with the parasii supports the view that the microfilaricidal action begins with the fixation of the drug to the microfilariae.

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Uptake of diethylcarbamazine by microfilariae and adults of Litomosoides carinii and Dipetalonema viteae

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