Uptake of prolactin from cerebrospinal fluid in rat brain

Steve Landas, Sue Ann Thompson, Rob Lewis, John F. Stamler, Mohan K. Raizada, M. Ian Phillips

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The fate of prolactin in the cerebrospinal fluid was studied by the use of fluorescein labelled prolactin. The distribution was compared to the immunocytochemical distribution of endogenous prolactin. High intensity fluorescence was found in the ependyma of the area postrema, rostral dorsolateral cerebral aqueduct close to the subcommissural organ, and in some cells of the floor of the cerebral aqueduct. This distribution was not seen when excess unlabelled prolactin was injected. The results suggest prolactin uptake from CSF at specific sites which correspond to sites of localization of immunoreactive prolactin.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
Issue number2
StatePublished - Dec 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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