Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Xiaoyu Chen, Jing Guo, Yunlong Huang, Shan Liu, Ying Huang, Zezhong Zhang, Fang Zhang, Zhongbing Lu, Fang Li, Jialin C. Zheng, Wenjun Ding

Research output: Contribution to journalArticle

Abstract

Main finding: Intranasal instillation PM2.5 induces neurotoxicity through its metal contents and glutaminase-containing extracellular vesicles (EVs) in olfactory bulbs of mice.

Original languageEnglish (US)
Article number114716
JournalEnvironmental Pollution
Volume264
DOIs
StatePublished - Sep 2020

Keywords

  • Extracellular vesicles
  • Glutamate
  • Glutaminase
  • Neurotoxicity
  • Olfactory bulb
  • PM

ASJC Scopus subject areas

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

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