Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Xiaoyu Chen; Jing Guo; Yunlong Huang; Shan Liu; Ying Huang; Zezhong Zhang; Fang Zhang; Zhongbing Lu; Fang Li; Jialin C. Zheng; Wenjun Ding

doi:10.1016/j.envpol.2020.114716

Urban airborne PM_2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

Xiaoyu Chen, Jing Guo, Yunlong Huang, Shan Liu, Ying Huang, Zezhong Zhang, Fang Zhang, Zhongbing Lu, Fang Li, Jialin C. Zheng, Wenjun Ding

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Main finding: Intranasal instillation PM_2.5 induces neurotoxicity through its metal contents and glutaminase-containing extracellular vesicles (EVs) in olfactory bulbs of mice.

Original language	English (US)
Article number	114716
Journal	Environmental Pollution
Volume	264
DOIs	https://doi.org/10.1016/j.envpol.2020.114716
State	Published - Sep 2020

Keywords

Extracellular vesicles
Glutamate
Glutaminase
Neurotoxicity
Olfactory bulb
PM

ASJC Scopus subject areas

Toxicology
Pollution
Health, Toxicology and Mutagenesis

Access to Document

10.1016/j.envpol.2020.114716

Cite this

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title = "Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb",

abstract = "Main finding: Intranasal instillation PM2.5 induces neurotoxicity through its metal contents and glutaminase-containing extracellular vesicles (EVs) in olfactory bulbs of mice.",

keywords = "Extracellular vesicles, Glutamate, Glutaminase, Neurotoxicity, Olfactory bulb, PM",

author = "Xiaoyu Chen and Jing Guo and Yunlong Huang and Shan Liu and Ying Huang and Zezhong Zhang and Fang Zhang and Zhongbing Lu and Fang Li and Zheng, {Jialin C.} and Wenjun Ding",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

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doi = "10.1016/j.envpol.2020.114716",

language = "English (US)",

volume = "264",

journal = "Environmental Pollution",

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T1 - Urban airborne PM2.5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb

AU - Chen, Xiaoyu

AU - Guo, Jing

AU - Huang, Yunlong

AU - Liu, Shan

AU - Huang, Ying

AU - Zhang, Zezhong

AU - Zhang, Fang

AU - Lu, Zhongbing

AU - Li, Fang

AU - Zheng, Jialin C.

AU - Ding, Wenjun

PY - 2020/9

Y1 - 2020/9

N2 - Main finding: Intranasal instillation PM2.5 induces neurotoxicity through its metal contents and glutaminase-containing extracellular vesicles (EVs) in olfactory bulbs of mice.

AB - Main finding: Intranasal instillation PM2.5 induces neurotoxicity through its metal contents and glutaminase-containing extracellular vesicles (EVs) in olfactory bulbs of mice.

KW - Extracellular vesicles

KW - Glutamate

KW - Glutaminase

KW - Neurotoxicity

KW - Olfactory bulb

KW - PM

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DO - 10.1016/j.envpol.2020.114716

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JO - Environmental Pollution

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