TY - JOUR
T1 - Urban-rural differences in breast cancer incidence in Egypt (1999-2006)
AU - Dey, Subhojit
AU - Soliman, Amr S.
AU - Hablas, Ahmad
AU - Seifeldein, Ibrahim A.
AU - Ismail, Kadry
AU - Ramadan, Mohamed
AU - El-Hamzawy, Hesham
AU - Wilson, Mark L.
AU - Banerjee, Mousumi
AU - Boffetta, Paolo
AU - Harford, Joe
AU - Merajver, Sofia D.
N1 - Funding Information:
The Gharbiah population-based cancer registry, founded in 1998 as a part of the Middle East Cancer Consortium (MECC) and funded by the U.S. National Cancer Institute (NCI), is located in Tanta, the capital of Gharbiah province. 22,23 Through an active registration process, data on cancer cases are collected from various sources in the province. For this study, most BC cases came from three locations; the Tanta Cancer Center (40–50%), Gharbiah Cancer Society (10–12%) and Tanta University Hospital (10–12%). Data obtained from these hospitals and centers using the International Agency for Research on Cancer (IARC) software CanReg4. Registrars were trained in data extraction and entry methods, and are periodically monitored by faculty of Emory School of Public Health, IARC, and the MECC. 22,23
Funding Information:
This work was supported by the Middle East Cancer Consortium, National Cancer Institute, Bethesda [R25 CA112383, R03 CA117350,5 P30 CA46592], the Burroughs Wellcome Fund [SDM], and the Breast Cancer Research Foundation [SDM]. Block Grant of the Department of Epidemiology, University of Michigan School of Public Health; and the Travel Grant of the Rackham Graduate School of the University of Michigan to [SD].
PY - 2010/10
Y1 - 2010/10
N2 - Objective: To describe urban-rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer. Methods: We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban-rural classification. Incidence patterns of breast cancer by district and age-specific urban-rural differences were analyzed. Results: Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/105-year for urban areas versus 17.8/105-year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla. Conclusions: Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances.
AB - Objective: To describe urban-rural differences in breast cancer incidence in Gharbiah, Egypt and to investigate if these differences could be explained by known risk factors of breast cancer. Methods: We used data from the population-based cancer registry of Gharbiah, Egypt to assess breast cancer incidence from 1999 through 2006. The Egyptian census provided data on district-specific population, age, and urban-rural classification. Incidence patterns of breast cancer by district and age-specific urban-rural differences were analyzed. Results: Overall, incidence rate of breast cancer was three to four times higher in urban areas than in rural areas (60.9/105-year for urban areas versus 17.8/105-year for rural areas; IRR=3.73, 95% CI=3.30, 4.22). Urban areas had consistently higher incidence of breast cancer across all age-groups for all years. Higher incidence of breast cancer was also seen in the more developed districts of Tanta and El-Mehalla. Conclusions: Higher incidence of breast cancer in urban and more developed populations might be related to higher exposure to xenoestrogens, as well as other endocrine disruptors and genotoxic substances.
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U2 - 10.1016/j.breast.2010.04.005
DO - 10.1016/j.breast.2010.04.005
M3 - Article
C2 - 20452771
AN - SCOPUS:77957132595
SN - 0960-9776
VL - 19
SP - 417
EP - 423
JO - Breast
JF - Breast
IS - 5
ER -