Uremia alters HDL composition and function

Michael Holzer, Ruth Birner-Gruenberger, Tatjana Stojakovic, Dalia El-Gamal, Veronika Binder, Christian Wadsack, Akos Heinemann, Gunther Marsche

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182 Scopus citations

Abstract

Functional impairment of HDL may contribute to the excess cardiovascular mortality experienced by patients with renal disease but the effect of advanced renal disease on the composition and function of HDL is not well understood. Here we used mass spectrometry and biochemical analyses to study alterations in the proteome and lipid composition of HDL isolated from patients on maintenance hemodialysis. We identified a significant increase in the amount of acute phase protein serum amyloid A1 albumin lipoprotein-associated phospholipase A2 and apoC-III composing uremic HDL. Furthermore uremic HDL contained reduced phospholipid and increased triglyceride and lysophospholipid. With regard to function these changes impaired the ability of uremic HDL to promote cholesterol efflux from macrophages. In summary the altered composition of HDL in renal disease seems to inhibit its cardioprotective properties. Assessing HDL composition and function in renal disease may help identify patients at increased risk for cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1631-1641
Number of pages11
JournalJournal of the American Society of Nephrology
Volume22
Issue number9
DOIs
StatePublished - Sep 2011

ASJC Scopus subject areas

  • Nephrology

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    Holzer, M., Birner-Gruenberger, R., Stojakovic, T., El-Gamal, D., Binder, V., Wadsack, C., Heinemann, A., & Marsche, G. (2011). Uremia alters HDL composition and function. Journal of the American Society of Nephrology, 22(9), 1631-1641. https://doi.org/10.1681/ASN.2010111144