Use of a Pulmonary Artery Pressure Sensor to Manage Patients with Left Ventricular Assist Devices

Vinay Thohan, Jacob Abraham, Adam Burdorf, Nasir Sulemanjee, Brian Jaski, Maya Guglin, Francis D. Pagani, Himabindu Vidula, David T. Majure, Rebecca Napier, Thomas J. Heywood, Rebecca Cogswell, Nicholas Dirckx, David J. Farrar, Stavros G. Drakos

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: Hemodynamic-guided management with a pulmonary artery pressure sensor (CardioMEMS) is effective in reducing heart failure hospitalization in patients with chronic heart failure. This study aims to determine the feasibility and clinical utility of the CardioMEMS heart failure system to manage patients supported with left ventricular assist devices (LVADs). Methods: In this multicenter prospective study, we followed patients with HeartMate II (n=52) or HeartMate 3 (n=49) LVADs and with CardioMEMS PA Sensors and measured pulmonary artery pressure, 6-minute walk distance, quality of life (EQ-5D-5 L scores), and heart failure hospitalization rates through 6 months. Patients were stratified as responders (R) and nonresponders to reductions in pulmonary artery diastolic pressure (PAD). Results: There were significant reductions in PAD from baseline to 6 months in R (21.5-16.5 mm Hg; P<0.001), compared with an increase in NR (18.0-20.3; P=0.002), and there was a significant increase in 6-minute walk distance among R (266 versus 322 meters; P=0.025) compared with no change in nonresponder. Patients who maintained PAD <20 compared with PAD ≥20 mm Hg for more than half the time throughout the study (averaging 15.6 versus 23.3 mm Hg) had a statistically significant lower rate of heart failure hospitalization (12.0% versus 38.9%; P=0.005). Conclusions: Patients with LVAD managed with CardioMEMS with a significant reduction in PAD at 6 months showed improvements in 6-minute walk distance. Maintaining PAD <20 mm Hg was associated with fewer heart failure hospitalizations. Hemodynamic-guided management of patients with LVAD with CardioMEMS is feasible and may result in functional and clinical benefits. Prospective evaluation of ambulatory hemodynamic management in patients with LVAD is warranted. Registration: URL:; Unique identifier: NCT03247829.

Original languageEnglish (US)
Pages (from-to)E009960
JournalCirculation: Heart Failure
Issue number6
StatePublished - Jun 1 2023


  • heart failure
  • hemodynamics
  • left ventricular assist device
  • pulmonary artery pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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